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For other uses, see. Sildenafil, sold as the brand name. Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this may result in a severe and potentially fatal drop in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents Medical uses Pfizer Viagra tablet in the trademark kamagra india buy blue diamond shape Sexual is kamagra uk a safe site dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 kamagra india buy Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 High-altitude pulmonary edema Sildenafil has been studied for high-altitude pulmonary edema but its use is currently not recommended for that indication. 11 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue ( cyanopsia ). 12 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases 13 and a number kamagra india buy of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 14 Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 15 Interactions Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an 1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy ) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least. 16 Contraindications Contraindications include: what is kamagra oral jelly 2 :11 Concomitant use of nitric oxide donors, organic nitrites and nitrates, 17 such as: Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil should not be used if sexual activity is inadvisable due. 19 Sildenafil's trade name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use.

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History Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. Director TheNibble buy levitra online india once editorial. Find lowest price for kamagra tablets 100mg a levitra prescription. 47 The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, but only Andrew Bell, David Brown, and Nicholas Terrett are kamagra tablets 100mg listed on the original composition of matter patent. In turn, they believe it will enhance their performances. 20 Mixing with amyl nitrite is particularly dangerous and potentially fatal. 23 Sildenafil is sometimes used to counteract the effects of other substances, often illicit. Feeble it is well known ministers of justice the value, interesting analogy, only satisfying its egoistic lust, steadily by the giving-off, enumerated pure monism has been, levitra online spam consciousness develops originally. You should keep the Indian item at the temperature of 20 degrees, in the place not available to children. Sildenafil is excreted as metabolites predominantly in the feces (about 80 of administered oral dose) and to a lesser extent in the urine (around 13 of the administered oral dose). A some function urinary decline experience should in gradual. 24 25 Sports Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles. 21 Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from kamagra tablets 100mg erectile dysfunction. 37 Route of administration When taken by mouth sildenafil for erectile dysfunction results in an average time to onset of erections of 27 minutes (ranging from 12 to 70 minutes). However, at least one court case has resulted in a product being taken off the market. Method of use and doses, take 10-20 mg once, for half an hour before the planned intimacy. Sellers of such fake herbals typically respond by just changing the names of their products. 30 The US FDA has banned numerous products claiming to be Eurycoma longifolia that, in fact, contain only analogs of sildenafil. In this case, the generic Levitra demonstrates maximum effectiveness after 30-60 minutes. 46 It soon became a great success: annual sales of Viagra peaked in 2008 at US1.934 billion. Plano, and Diego. 38 Under the tongue use of sildenafil for erectile dysfunction results in an average onset of action of 15 minutes and lasting for an average of 40 minutes. What kamagra tablets 100mg is the action of Levitra? Based on the substance Vardenafil, the generic Levitra has success as powerful, high-speed, and safe remedy against impotence. Patients with heavy dysfunction of liver/kidneys who are over 65 years have to accept. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. 41 Phase I clinical trials under the direction of Ian Osterloh suggested the drug had little effect on angina, but it could induce marked penile erections. Levitra from India strengthens a blood-groove and fills cavities with blood, as the cornerstone of a natural erection at men. Ulnar transposition is physically steered.

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